Light-triggered chemical amplification to accelerate degradation and release from polymeric particles† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5cc06143a Click here for additional data file.

Nanoparticle “switch-on” by tetrazine triggering† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6cc05118a Click here for additional data file. Click here for additional data file. Click here for additional data file.

This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels-Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent d...

Light-triggered chemical amplification to accelerate degradation and release from polymeric particles.

We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.

DNA cross-triggered cascading self-amplification artificial biochemical circuit† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc03225j Click here for additional data file.

A counteranion triggered arylation strategy using diaryliodonium fluorides† †Electronic supplementary information (ESI) available: Experimental data for all new compounds and procedures. See DOI: 10.1039/c4sc02856b Click here for additional data file. Click here for additional data file.

An unprecedented amplification of near-infrared emission in a Bodipy derived π-system by stress or gelation† †Electronic supplementary information (ESI) available: Experimental details, synthesis procedures and characterization data of the compounds, and additional figures. CCDC 1523313. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc01696d Click here for additional data file. Click here for additional data file.